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Updated: Mar 27, 2026
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The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia
Published on: November 30, 2016
17.4K
Omics/systems biology and cancer cachexia
Iain J Gallagher1, Carsten Jacobi2, Nicolas Tardif3
1Health and Exercise Research Group, University of Stirling, Stirling FK9 4LA, UK.
Seminars in Cell & Developmental Biology
|January 20, 2016
Summary
Cancer cachexia is a complex syndrome. Systems biology and
Area of Science:
- Oncology and Systems Biology
Background:
- Cancer cachexia is a complex syndrome resulting from host-tumor interactions, treatment effects, and toxicity.
- The syndrome's complexity necessitates a holistic biological perspective, aligning with systems biology principles.
Purpose of the Study:
- To review the application of 'omics' technologies in understanding cancer cachexia.
- To explore the potential of systems biology approaches for identifying therapeutic targets in cancer cachexia.
Main Methods:
- Review of recent applications of genomics, transcriptomics, proteomics, lipidomics, and metabolomics.
- Focus on studies addressing muscle atrophy and cancer cachexia.
Main Results:
- 'Omics' technologies offer a global view of biological systems relevant to cancer cachexia.
- These technologies are crucial for generating systems-level models of cachexia.
Conclusions:
- Systems biology approaches are vital for uncovering key mechanisms in cancer cachexia.
- Integrating 'omics' data will advance the understanding of cachexia pathology and treatment pathways.
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