Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

6.9K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
6.9K
Notch Signaling Pathway03:14

Notch Signaling Pathway

6.5K
6.5K
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

2.6K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.6K
Cadherins in Tissue Organization01:19

Cadherins in Tissue Organization

4.5K
The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...
4.5K
Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

10.5K
Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved...
10.5K
Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

4.5K
4.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[A Case of Laparoscopic Lateral Segmentectomy for Metachronous Liver Metastasis from Cervical Cancer].

Gan to kagaku ryoho. Cancer & chemotherapy·2026
Same author

CD4<sup>+</sup> skin resident memory T cells preferentially colocalize with dermal Folr2<sup>hi</sup> macrophages in contact hypersensitivity.

Frontiers in immunology·2025
Same author

Neoadjuvant Chemotherapy Versus Adjuvant Chemotherapy for Very Low-Lying Clinical T3 Rectal Cancer: The NAIR Phase 2/3 Randomized Clinical Trial.

Annals of surgery open : perspectives of surgical history, education, and clinical approaches·2025
Same author

[A Case of Metachronous Liver Metastasis That Recurred 15 Years after Surgery for Sigmoid Colon Cancer].

Gan to kagaku ryoho. Cancer & chemotherapy·2025
Same author

High-resolution assessment of climate change impacts on the surface energy and water balance in the glaciated Naryn River basin, Central Asia.

Journal of environmental management·2025
Same author

Atlantic-origin water extension into the Pacific Arctic induced an anomalous biogeochemical event.

Nature communications·2023

Related Experiment Video

Updated: Mar 27, 2026

Cell Aggregation Assays to Evaluate the Binding of the Drosophila Notch with Trans-Ligands and its Inhibition by Cis-Ligands
05:48

Cell Aggregation Assays to Evaluate the Binding of the Drosophila Notch with Trans-Ligands and its Inhibition by Cis-Ligands

Published on: January 2, 2018

8.0K

Notch-Mediated Cell Adhesion.

Akihiko Murata1, Shin-Ichi Hayashi2

  • 1Department of Molecular and Cellular Biology, Division of Immunology, School of Life Science, Faculty of Medicine, Tottori University, Yonago, Tottori 683-8503, Japan. muratako@med.tottori-u.ac.jp.

Biology
|January 20, 2016
PubMed
Summary

Notch proteins are known signaling molecules but also function in cell adhesion. This review explores their ancestral roles in cell adhesion, potentially mediating multicellularity in early animals.

Keywords:
Delta/Delta-likeNotchSerrate/Jaggedcell adhesionmetazoan evolution

More Related Videos

Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules
08:15

Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules

Published on: October 17, 2014

11.0K
Stimulation of Notch Signaling in Mouse Osteoclast Precursors
08:01

Stimulation of Notch Signaling in Mouse Osteoclast Precursors

Published on: February 28, 2017

8.4K

Related Experiment Videos

Last Updated: Mar 27, 2026

Cell Aggregation Assays to Evaluate the Binding of the Drosophila Notch with Trans-Ligands and its Inhibition by Cis-Ligands
05:48

Cell Aggregation Assays to Evaluate the Binding of the Drosophila Notch with Trans-Ligands and its Inhibition by Cis-Ligands

Published on: January 2, 2018

8.0K
Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules
08:15

Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules

Published on: October 17, 2014

11.0K
Stimulation of Notch Signaling in Mouse Osteoclast Precursors
08:01

Stimulation of Notch Signaling in Mouse Osteoclast Precursors

Published on: February 28, 2017

8.4K

Area of Science:

  • Evolutionary biology
  • Cellular biology
  • Molecular biology

Background:

  • Notch proteins are primarily recognized as signaling molecules regulating cellular responses in metazoans.
  • Studies in flies and mammals reveal Notch proteins also function as cell adhesion molecules.
  • The physiological roles and evolutionary origin of Notch-mediated cell adhesion are not well understood.

Purpose of the Study:

  • To review the current understanding of Notch-mediated cell adhesion.
  • To explore the ancestral and potential physiological roles of Notch family members as cell adhesion molecules.
  • To investigate the evolutionary origin of Notch proteins, tracing their roles back to early metazoan evolution.

Main Methods:

  • Literature review of existing studies on Notch signaling and cell adhesion.
  • Comparative analysis of Notch family members across different metazoan species.
  • Hypothesis formulation based on evolutionary and functional data.

Main Results:

  • Notch proteins possess conserved cell adhesion functions across metazoans.
  • Evidence suggests Notch-mediated adhesion predates its signaling roles.
  • The ancestral function of Notch may have been crucial for establishing multicellularity.

Conclusions:

  • Notch family members likely originated as cell adhesion molecules.
  • This ancestral function may have been essential for the evolution of multicellularity in the last common ancestor of metazoans.
  • Further research is needed to fully elucidate the interplay between Notch adhesion and signaling in evolutionary history.