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EVALUATION OF THYROID TO BACKGROUND RATIOS AND COMPARISON OF VARIOUS SCINTIGRAPHIC MEASUREMENTS AND THEIR CORRELATION

Ann Bettencourt¹, Gregory B Daniel¹, David Panciera¹

¹Department of Small Animal Clinical Sciences, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, 24061.

Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association

|January 20, 2016

Summary

The thyroid-to-background ratio, using the heart region of interest, is a good predictor of feline hyperthyroidism. However, percent dose uptake and thyroid-to-salivary ratio are better indicators of thyroid function.

Keywords:

feline hyperthyroidism pertechnetate quantitative analysis thyroid scintigraphy thyroid-to-background ratio

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Area of Science:

Veterinary Nuclear Medicine
Comparative Endocrinology

Background:

Thyroid-to-salivary ratio and percent dose uptake are established scintigraphic metrics for hyperthyroidism.
Thyroid-to-background ratio is a proposed alternative but lacks validation.

Purpose of the Study:

Identify the optimal background region of interest (ROI) for blood pool activity.
Evaluate if thyroid-to-background ratio predicts thyroid function better than existing methods.

Main Methods:

Observational, cross-sectional, prospective study of 56 cats with hyperthyroidism.
Compared plasma radioactivity to 8 anatomic background ROIs.
Correlated scintigraphic ratios (thyroid-to-background, thyroid-to-salivary) and percent dose uptake with serum T4 levels.

Main Results:

Heart ROI showed the strongest correlation with plasma radioactivity (r=0.70).
Percent dose uptake (r=0.74) was the best predictor of serum T4, followed by thyroid-to-salivary ratio (r=0.66).
Thyroid-to-background ratio using the heart ROI (r=0.59) was a weaker predictor of serum T4.

Conclusions:

The heart ROI best reflects blood pool activity in scintigraphy.
Percent dose uptake and thyroid-to-salivary ratio are superior predictors of thyroid function compared to thyroid-to-background ratio in cats.