Related Experiment Video
Updated: Mar 27, 2026

Synthesis and Characterization of Placental Chondroitin Sulfate A plCSA-Targeting Lipid-Polymer Nanoparticles
Published on: September 18, 2018
Synthesis and Characterization of Fatty Acid Conjugates of Niacin and Salicylic Acid
Chi B Vu1, Jean E Bemis1, Ericka Benson1
1Catabasis Pharmaceuticals , One Kendall Square, Suite B14202, Cambridge, Massachusetts 02139, United States.
Abstract:
This report describes the synthesis and preliminary biological characterization of novel fatty acid niacin conjugates and fatty acid salicylate conjugates. These molecular entities were created by covalently linking two bioactive molecules, either niacin or salicylic acid, to an omega-3 fatty acid. This methodology allows the simultaneous intracellular delivery of two bioactives in order to elicit a pharmacological response that could not be replicated by administering the bioactives individually or in combination. The fatty acid niacin conjugate 5 has been shown to be an inhibitor of the sterol regulatory element binding protein (SREBP), a key regulator of cholesterol metabolism proteins such as PCSK9, HMG-CoA reductase, ATP citrate lyase, and NPC1L1. On the other hand, the fatty acid salicylate conjugate 11 has been shown to have a unique anti-inflammatory profile based on its ability to modulate the NF-κB pathway through the intracellular release of the two bioactives.
Related Concept Videos
Phase II Reactions: Sulfation and Conjugation with α-Amino Acids
Preparation of Carboxylic Acids: Hydrolysis of Nitriles
Overview of Fatty Acid Metabolism
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
Alkylation of β-Diester Enolates: Malonic Ester Synthesis
Nitriles to Carboxylic Acids: Hydrolysis
Drug Metabolism: Phase II Reactions

