[Hypotensive effect of hydrochlorothiazide and its combination with triamterene]

A comparative study of the antihypertensive effects of hydrochlorothiazide (HCT) monotherapy and of its combinations with triamterene (T), carried out in 57 patients with Stage II noncomplicated essential hypertension, have shown the best antihypertensive effect of 2 tablets of triampur (TP), containing 12.5 mg HCT and 25 mg T each; 25 mg of HCT have been less effective. Triampur more markedly reduced the systolic arterial pressure (APs) at rest, with the patient lying down. If the drug doses are doubled, TP intake leads to a somewhat more manifest reduction of APs than HCT. The pattern and the degree of orthostatic shifts are virtually unchanged by both the drugs. In exercise test neither TP nor HCT in the afore doses influenced the pattern and degree of the hemodynamic shifts. These results evidence that TP hypotensive effect and the underlying hemodynamic shifts are in fact identical in their pattern and manifestation to the effect of HCT alone and are mainly due to this latter drug.