[Various mechanisms of stimulating growth hormone secretion using growth hormone releasing factor and insulin-induced...

The response of the growth hormone was studied in 7 healthy individuals after single and combined insulin administration and administration of growth hormone releasing factor. Very high response of insulin and growth hormone releasing factor in comparison with single administration of these stimuli, was registered. The high elevation of the growth hormone during the combined insulin-growth hormone releasing factor administration was observed after the administration of the maximal dose of the growth hormone releasing factor. This fact suggested the existence of different mechanisms of these stimuli. This was the clinical confirmation of formerly established experimental proofs. On the basis of the analysis of these results it was established that the response of the growth hormone to insulin hypoglycaemia in comparison with growth hormone releasing factor stimulation was fast. This is of practical importance. The highest liberation of the growth hormone in men was achieved with the combined administration of insulin and growth hormone releasing factor. In this way a better evaluation of hypophyseal reserves of the growth hormone was possible.