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Related Concept Videos

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Related Experiment Video

Updated: Mar 26, 2026

Surface Functionalization of Hepatitis E Virus Nanoparticles Using Chemical Conjugation Methods
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Chemically activatable viral capsid functionalized for cancer targeting.

Chun-Chieh Chen1, Li Xing1, Marie Stark1

  • 1Department of Molecular & Cellular Biology, University of California, 1 Shields Ave, Davis, CA 95616, USA.

Nanomedicine (London, England)
|January 21, 2016
PubMed
Summary

Researchers engineered hepatitis E virus-like nanoparticles to create a theranostic capsule for breast cancer. This targeted cancer cells and remained immune silent, showing potential for diagnostics and therapeutics.

Keywords:
cycloaddition of targeting ligandcysteine replacementhepatitis Emultivalent ligand displayvirus-like particle

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Area of Science:

  • Biotechnology
  • Nanomedicine
  • Oncology

Background:

  • Hepatitis E virus-like particles (HEV VLP) are highly stable nanostructures.
  • Targeted delivery systems are crucial for effective cancer diagnostics and therapeutics.

Purpose of the Study:

  • To design a theranostic capsule for breast cancer using modified HEV VLP.
  • To functionalize HEV VLP with a breast cancer targeting ligand (LXY30) and a near-infrared fluorescence dye.

Main Methods:

  • Mutating surface-exposed residues to cysteine for conjugation.
  • Covalently conjugating the engineered HEV VLP to LXY30 and a fluorescent dye.

Main Results:

  • The LXY30-HEV VLP demonstrated binding and entry into breast cancer cell lines.
  • In vivo studies showed effective tumor targeting in mice.
  • The engineered nanoparticle was immune silent due to disrupted antibody-binding sites.

Conclusions:

  • Demonstrated the successful production of a theranostic capsule for cancer.
  • Surface modification of HEV VLP offers a promising platform for cancer diagnostics and therapeutics.