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Related Experiment Videos

[Oddi's sphincter dysfunction].

H Elbrønd, B Huniche, L Ostergaard

    Ugeskrift for Laeger
    |September 25, 1989
    PubMed
    Summary
    This summary is machine-generated.

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    Sphincter of Oddi dysfunction (SOD) can cause persistent upper abdominal pain after gallbladder removal. Elevated basal pressure in the sphincter of Oddi is a key indicator, and endoscopic sphincterotomy may offer relief.

    Area of Science:

    • Gastroenterology
    • Hepatobiliary Surgery

    Context:

    • Persistent upper abdominal pain post-cholecystectomy, excluding other pathologies, suggests Sphincter of Oddi dysfunction (SOD).
    • Pathogenesis of SOD is not fully understood, potentially involving post-surgical spasm or biliary pressure sensitivity.
    • Fibrosis or stenosis of the Sphincter of Oddi (SO) as an etiology remains unclear.

    Purpose:

    • To highlight the importance of considering SOD in unexplained post-cholecystectomy pain.
    • To discuss diagnostic approaches, including Endoscopic Retrograde Cholangiopancreatography (ERCP) with papillary manometry.
    • To evaluate treatment options, such as endoscopic sphincterotomy for refractory cases.

    Summary:

    • Endoscopic retrograde cholangiopancreatography (ERCP) with papillary manometry is recommended for suspected SOD.

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  • Elevated basal pressure in the Sphincter of Oddi (SO) is the most reliable diagnostic indicator.
  • Endoscopic sphincterotomy shows promise, particularly for patients with elevated SO basal pressure, though further evaluation is needed.

    • Impact:

    • Improved diagnostic criteria for Sphincter of Oddi dysfunction (SOD).
    • Potential for effective therapeutic intervention through endoscopic sphincterotomy.
    • Highlights the need for further research into SO physiology and regulation.