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Related Concept Videos

Varicose Veins I: Introduction01:26

Varicose Veins I: Introduction

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Varicose veins, or varicosities, are abnormally dilated and twisted superficial veins caused by venous valve incompetence. This condition commonly affects the lower extremities, especially the saphenous veins, due to the higher pressure from prolonged standing and walking. However, varicosities can also occur in other areas, such as the esophagus, vulva, spermatic cords, and anorectal region.Etiology and typesPrimary varicose veins, often idiopathic, are more common in women due to inherent...
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Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

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Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
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Varicose Veins II: Diagnostic Studies and Interprofessional Care01:26

Varicose Veins II: Diagnostic Studies and Interprofessional Care

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Varicose veins, or varicosities, develop when the valves in the veins, which control blood flow, weaken or damage. It causes blood to pool and the veins to enlarge. Understanding the clinical manifestations, diagnostic approaches, and management options for varicose veins is crucial for effective treatment and relief.Clinical manifestationsClinical manifestations of varicose veins include a heavy, achy feeling or pain after prolonged standing or sitting. This discomfort can often be relieved by...
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Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

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The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
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Venous Thrombosis IV: Nursing Management01:30

Venous Thrombosis IV: Nursing Management

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Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
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Venous Return01:04

Venous Return

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The circulatory system plays a crucial role in ensuring the optimal functioning of the human body. One of its critical components is venous return - the process that completes the blood circulation cycle. This article will delve into the concept of venous return, how it works, and its significance to our health.
What is Venous Return?
Venous return refers to the rate at which blood flows back to the heart from the body's peripheral veins. It's an integral part of the circulatory system...
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Updated: Mar 26, 2026

Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane
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Genetics in chronic venous disease.

Yasmin Grant1, Sarah Onida1, Alun Davies1

  • 1Academic Section of Vascular Surgery, Division of Surgery, Department of Surgery & Cancer, Imperial College London, Charing Cross Hospital, London, UK.

Phlebology
|January 21, 2016
PubMed
Summary

Genetic factors significantly influence chronic venous disease (CVD) and varicose veins. International collaboration using genome-wide studies is crucial for understanding CVD genetics and improving patient outcomes.

Keywords:
Chronic venous diseasevaricose veins

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Area of Science:

  • Genetics
  • Vascular Biology
  • Epidemiology

Background:

  • Chronic venous disease (CVD) is a prevalent condition, with varicose veins as its primary manifestation.
  • Genetic factors are increasingly recognized as significant contributors to the etiology and pathology of CVD.
  • Current understanding of specific genes involved in CVD remains limited, and many past studies lack robust methodologies.

Purpose of the Study:

  • To highlight the need for systematic genetic research in chronic venous disease.
  • To advocate for the application of high-throughput genotyping and genome-wide association studies.
  • To emphasize the potential of genetic discoveries for improved prevention and treatment strategies.

Main Methods:

  • Review of existing literature on genetic influences in venous disease.
  • Discussion of the potential of high-throughput genotyping platforms.
  • Proposal for a collaborative, international, genome-wide case-control association study.

Main Results:

  • Substantial evidence supports a genetic basis for chronic venous disease.
  • Genome-wide approaches offer the potential to identify novel metabolic pathways and genetic susceptibility factors.
  • Current genetic studies often lack adherence to fundamental research principles.

Conclusions:

  • Further research is needed to elucidate the precise genetic architecture of chronic venous disease.
  • International collaboration and standardized genome-wide studies are essential for robust findings.
  • Understanding the genetics of CVD promises advancements in patient care and clinical sequelae management.