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Updated: Mar 26, 2026
Microfabrication of Nanoporous Gold Patterns for Cell-material Interaction Studies
Published on: July 15, 2013
A facile method to in situ fabricate three dimensional gold nanoparticle micropatterns in a cell-resistant hydrogel
Ming-Hao Yao1, Jie Yang, Dong-Hui Zhao
1Britton Chance Center for Biomedical Photonics at Wuhan National Laboratory for Optoelectronics - Hubei Bioinformatics & Molecular Imaging Key Laboratory, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Hubei, Wuhan 430074, P. R. China. zydi@mail.hust.edu.cn lbyang@mail.hust.edu.cn.
Abstract:
A facile method for in situ fabrication of three-dimensional gold nanoparticle micropatterns in a cell-resistant polyethylene glycol hydrogel has been developed by combining photochemical synthesis of gold nanoparticles with photolithography technology. The gold nanoparticle micropatterns were further bio-modified with cell integrated polypeptide NcysBRGD based on a gold-thiol bond to improve cell behaviors. Primary cell tests showed that NcysBRGD can enhance cell adhesion very well on the surface of gold nanoparticle micropatterns.
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