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Multi-omics enrichment analysis using the GeneTrail2 web service.

Daniel Stöckel1, Tim Kehl1, Patrick Trampert1

  • 1Center for Bioinformatics, Saarland University, Saarbrücken D-66041.

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Summary

GeneTrail2 integrates multiple omics data for comprehensive analysis. This tool aids in discovering pathogenic mechanisms and biomarkers for diseases like Wilms tumors.

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Area of Science:

  • Bioinformatics
  • Computational Biology
  • Genomics

Background:

  • High-throughput transcriptomic data analysis is crucial.
  • Multi-omics datasets require integrated analysis tools.
  • Gene set analysis has advanced omics data interpretation.

Purpose of the Study:

  • To present GeneTrail2, a web service for integrated multi-omics data analysis.
  • To enable comparison and exploration of transcriptomic, miRNomic, genomic, and proteomic datasets.
  • To apply GeneTrail2 to investigate Wilms tumor pathogenesis.

Main Methods:

  • GeneTrail2 integrates transcriptomic, miRNomic, genomic, and proteomic data.
  • The service offers multiple statistical tests and biological categories.
  • Direct comparison of computed results is enabled.

Main Results:

  • GeneTrail2 successfully explored pathogenic mechanisms in Wilms tumors.
  • Signaling cascades contributing to blastemal subtype malignancy were revealed.
  • Potential biomarkers for nephroblastoma with adverse prognosis were identified.

Conclusions:

  • GeneTrail2 is a powerful tool for integrated multi-omics analysis.
  • The tool can elucidate complex pathogenic mechanisms in cancer and other diseases.
  • GeneTrail2 facilitates the discovery of disease biomarkers.