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Predictive Value for Galectin 3 and Cardiotrophin 1 in Hemodialysis Patients

Simona Hogas1, Adalbert Schiller2, Luminita Voroneanu3

  • 1Nephrology Department, Dialysis and Renal Transplant Center, "C.I. Parhon" University Hospital, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania.

Angiology
|January 21, 2016
PubMed

Insights

Galectin 3 (GAL-3) predicts mortality in hemodialysis patients. Elevated GAL-3 levels indicate a higher risk of death for those with end-stage renal disease on hemodialysis.

Area of Science:

  • Cardiovascular Medicine
  • Nephrology
  • Biomarker Research

Background:

  • End-stage renal disease (ESRD) patients face elevated all-cause mortality risks.
  • Prognostic value of novel cardiac biomarkers cardiotrophin 1 (CT-1) and galectin 3 (GAL-3) remains unclear in hemodialysis (HD) patients.

Purpose of the Study:

  • To assess the predictive capability of CT-1 and GAL-3 for mortality in HD patients.
  • To determine if these novel biomarkers can identify high-risk individuals within the HD population.

Main Methods:

  • Plasma concentrations of GAL-3 and CT-1 were measured at baseline in 88 HD patients.
  • Patients were followed for an average of 22.2 months, during which mortality events were recorded.
  • Cox proportional hazards models were used to analyze the prognostic value of GAL-3 and CT-1.

Main Results:

  • A total of 21 deaths (23.9%) occurred during the follow-up period.
  • Galectin 3 (GAL-3) above 23.73 ng/mL was identified as an independent predictor of mortality (HR 2.60).
  • Cardiotrophin 1 (CT-1) did not show significant prognostic value in this cohort.

Conclusions:

  • Galectin 3 (GAL-3) is an independent predictor of all-cause mortality in hemodialysis patients.
  • Similar to the general population, GAL-3 holds prognostic significance for mortality risk in HD patients.
  • These findings support the potential clinical utility of GAL-3 in risk stratification for ESRD patients undergoing hemodialysis.

Keywords:
cardiotrophin 1chronic kidney diseasegalectin 3hemodialysismortality

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