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[Effect of pimobendan on peripheral hemodynamics]
P Peters1, F Saborowski, A Kothe
1Medizinische Klinik Holweide, Universität zu Köln.
Zeitschrift Fur Kardiologie
|August 1, 1989
Summary
Pimobendan increased forearm blood flow and heart rate, while reducing vascular resistance in healthy volunteers and coronary artery disease patients. This study investigated its hemodynamic effects.
Area of Science:
- Cardiovascular Physiology
- Pharmacology
Background:
- Coronary artery disease (CAD) impacts peripheral hemodynamics.
- Understanding drug effects on circulation is crucial for patient management.
Purpose of the Study:
- To evaluate the effects of pimobendan on peripheral hemodynamics and metabolic parameters in patients with CAD and healthy volunteers.
- To compare pimobendan's effects against a placebo in a randomized, double-blind study.
Main Methods:
- Peripheral hemodynamics were assessed using venous occlusion plethysmography.
- Measurements were taken at rest and during isometric handgrip exercise.
- A randomized, double-blind, placebo-controlled design was employed.
Main Results:
- Pimobendan significantly increased forearm blood flow (9-38%) and heart rate (14-19%) in all groups.
- Local forearm resistance decreased by 13-22% with pimobendan.
- No significant changes in blood pressure or metabolic parameters were observed.
Conclusions:
- Pimobendan demonstrates vasodilatory properties, improving peripheral blood flow and reducing resistance.
- The drug elevates heart rate without altering blood pressure, suggesting a specific hemodynamic profile.
- Pimobendan does not affect metabolic parameters in the studied populations.