Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Solubility studies of silver sulfonamides.

R U Nesbitt, B J Sandmann

    Journal of Pharmaceutical Sciences
    |July 1, 1978
    PubMed
    Summary

    The solubility of silver sulfonamides increases with acidity, mirroring protonation of their amino groups. This behavior varies among different silver sulfonamide compounds.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Direct medical charges associated with myocardial infarction in patients with and without diabetes.

    Medical care·1999
    Same author

    Stability studies of gabapentin in aqueous solutions.

    Pharmaceutical research·1992
    Same author

    Gastrointestinal behavior of orally administered radiolabeled erythromycin pellets in man as determined by gamma scintigraphy.

    Journal of clinical pharmacology·1990
    Same author

    Manufacture and properties of erythromycin beads containing neutron-activated erbium-171.

    Pharmaceutical research·1990
    Same author

    Liquid expressions. What they really mean.

    American pharmacy·1988
    Same author

    A potentiometric study of lithium complexation with catecholamines.

    Journal of pharmaceutical sciences·1986

    Area of Science:

    • Pharmaceutical Chemistry
    • Medicinal Chemistry
    • Analytical Chemistry

    Background:

    • Silver sulfonamides are a class of compounds with antimicrobial properties.
    • Understanding their solubility is crucial for formulation and predicting in vivo behavior.
    • Previous research has not fully elucidated the pH-dependent solubility of various silver sulfonamides.

    Purpose of the Study:

    • To determine the solubility of silver sulfapyridine, silver sulfamethazine, and silver sulfamethizole across a range of pH values.
    • To investigate the relationship between solubility, pH, and the protonation state of the p-amino group.
    • To compare the ionization behavior and physical properties of these silver sulfonamides.

    Main Methods:

    • Solubility measurements were conducted using nitric acid-potassium nitrate, acetate, and sulfonic acid buffers.
    • Silver-ion concentration was quantified using a silver-ion selective electrode.
    • Total silver concentration was determined via known subtraction and known addition methods.

    Main Results:

    • All tested silver sulfonamides exhibited increased solubility with higher hydrogen-ion concentration (lower pH).
    • This solubility trend correlated directly with the protonation of the sulfonamide's p-amino function.
    • Silver sulfamethizole and silver sulfamethazine showed complete ionization in solution, while silver sulfapyridine ionized completely only at pH 2-3.

    Conclusions:

    • The pH-dependent solubility of silver sulfonamides is governed by the protonation of the p-amino group.
    • Differences in ionization behavior were observed among silver sulfapyridine, silver sulfamethazine, and silver sulfamethizole.
    • Silver sulfadiazine possesses a unique set of physical properties compared to other silver sulfonamides with available mortality data.

    Related Experiment Videos