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Updated: Mar 26, 2026

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
Published on: February 28, 2019
Olfactory neuroblastoma: A case report.
Gonca Hanedan Uslu1, Emine Canyilmaz2, Ahmet Yasar Zengin1
1Department of Radiation Oncology, Faculty of Medicine, Kanuni Research and Education Hospital, Trabzon 61040, Turkey.
Olfactory neuroblastoma, a rare nasal cavity cancer, was treated in a 69-year-old patient using surgery and radiotherapy. This study discusses esthesioneuroblastoma treatment options and literature.
Area of Science:
- Oncology
- Otorhinolaryngology (ENT)
- Neurosurgery
Background:
- Olfactory neuroblastoma (ON), also known as esthesioneuroblastoma, is a rare malignancy originating from olfactory neuroepithelial cells.
- This cancer accounts for less than 3% of nasal cavity tumors and can invade sinuses, orbits, and the cranium.
- ON is characterized by slow growth and a tendency for local recurrence.
Purpose of the Study:
- To report a case of olfactory neuroblastoma treated with combined surgical excision and radiotherapy.
- To discuss the literature regarding esthesioneuroblastoma and its treatment modalities.
Main Methods:
- A case study of a 69-year-old patient presenting with a nasal cavity mass.
- Treatment involved surgical excision followed by radiotherapy.
- Literature review on olfactory neuroblastoma and its management.
Main Results:
- The patient underwent successful combined surgical excision and radiotherapy.
- The study provides insights into the management of esthesioneuroblastoma.
Conclusions:
- Combined surgical excision and radiotherapy represent a viable treatment option for olfactory neuroblastoma.
- Further research and case studies are valuable for understanding and optimizing esthesioneuroblastoma treatment.
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