[Design and synthesis of LHRH analogs]

In the hope to find new superagonists of LHRH, here we report the synthesis of six analogs by changing residue 5 of [D-Trp6 (or D-Arg6), des-Gly10]-LHRH-EA. For the convenience of comparison, the known compound [D-Trp6, desGly10]-LHRH-EA was also synthesized.