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Updated: Mar 26, 2026
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Published on: April 25, 2016
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IDENTIFICATION OF POTENTIAL MARKERS FOR CUSHING DISEASE
Summary
Cushing disease (CD) diagnosis can be improved by identifying key symptom combinations. Uncommon symptom pairs, like osteoporosis and obesity, significantly increase the relative risk, aiding earlier detection of this rare condition.
Area of Science:
- Endocrinology
- Medical Informatics
Background:
- Cushing disease (CD) presents with diverse, nonspecific symptoms, often leading to diagnostic delays.
- International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes can help identify symptom patterns.
- Identifying symptom dyads may improve early diagnosis of CD.
Purpose of the Study:
- To identify and evaluate dyads of clinical symptoms or conditions associated with CD.
- To assess the relative risk (RR) of individual conditions and symptom combinations in CD patients versus controls.
Main Methods:
- A matched case-control study was conducted.
- A commercial healthcare insurance claims database was utilized.
- Ten key conditions were selected by expert endocrinologists.
Main Results:
- Individual conditions had high RRs, ranging from 5.3 for osteoporosis to 61.0 for hirsutism.
- Dyads of conditions showed even higher RRs, from 4.1 to 128.0.
- Uncommon dyads, such as osteoporosis and obesity, demonstrated significantly elevated RRs (e.g., 52.0).
Conclusions:
- The relative risk for any single key condition was at least 5 times greater in CD patients.
- Most symptom dyads had an RR of 5 or greater, indicating strong association with CD.
- Considering CD in patients presenting with high-risk symptom combinations can improve early diagnosis.
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