[Application of transmission and scanning electron microscopy in experimental obstructive uropathy: III. Lesions at...

In experimental obstructive uropathy the renal interstice undergoes profound modifications, from the earliest stages, with the fibroblastic elements adopting a palisade arrangement between the renal tubules and the blood cells. Between these cells there is a marked edema configuring "canals", which could be the morphological image of the tubulovenous reflux described in obstructive uropathy. these routes, which we will call tubule-interstice-vein "canals", since in no case could we verify the existence of a direct communication between the tubule formations and the veins, disappear in animals put down late, where fibro and myofibroblastic elements, round cells and macrophages proliferate. A larger number of fibres and fundamental substance are also found. As a result of these changes, a great alteration in renal architecture takes place.