Mutations in TUBB8 and Human Oocyte Meiotic Arrest

Ruizhi Feng¹, Qing Sang, Yanping Kuang+30

• ¹From the State Key Laboratory of Genetic Engineering, Institutes of Biomedical Sciences, MOE Key Laboratory of Contemporary Anthropology, and Collaborative Innovation Center of Genetics and Development, School of Life Sciences, Fudan University (R.F., Q.S., Y.X., R.Q., X.W., H.W., Q.L., Q.X., L.J., L.H., L.W.), Shanghai Ji Ai Genetics and IVF Institute, Obstetrics and Gynecology Hospital, Fudan University (X.S., M.Y., J.C.), Department of Otolaryngology, Eye and ENT Hospital, Fudan University (L.G.), Department of Integrative Medicine and Neurobiology, State Key Laboratory of Medical Neurobiology, and Shanghai Medical College, Fudan University (Y.F.), the Reproductive Medicine Center, Shanghai Ninth Hospital, Shanghai Jiao Tong University (Y.K., Z.Y., S.Z., B.L.), Shanghai Institute of Planned Parenthood Research (Z.S., M.L., H.S.), and Bio-X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University (L.H.), Shanghai, Reproductive Medicine Center, Shaanxi Maternal and Child Care Service Center, Shaanxi (J.S.), and Key Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast University, Nanjing (R.C.) - all in China; the Department of Biochemistry and Molecular Pharmacology, New York University Langone Medical Center, New York (G.T., N.J.C.); the Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago (A.L., Y. Fukuda, M.L.G.); the Department of Physiology-Endocrinology, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden (R.S.); the Department of Genetics, Development and Cell Biology, Iowa State University, Ames (M.L.G.); and the Life Sciences Division, Lawrence Berkeley National Laboratory (R.Z., E.N.), the Molecular and Cell Biology Department (E.N.), and the Howard Hughes Medical Institute (E.N.), University of California Berkeley, Berkeley.