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Related Experiment Videos

Renal dysfunction resulting from NSAIDs.

G L Bakris1, S R Kern

  • 1Ochsner Clinic, New Orleans, Louisiana.

American Family Physician
|October 1, 1989
PubMed
Summary

Nonsteroidal anti-inflammatory drugs (NSAIDs) can cause acute kidney injury. NSAID-induced nephritis presents differently than antibiotic-related nephritis, with more proteinuria and fewer allergic signs. Steroid therapy efficacy for NSAID nephritis is uncertain.

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Area of Science:

  • Nephrology
  • Pharmacology

Background:

  • Nonsteroidal anti-inflammatory drugs (NSAIDs) are a frequent cause of acute kidney injury.
  • NSAID-induced acute tubulointerstitial nephritis has distinct clinical features compared to antibiotic-induced nephritis.

Purpose of the Study:

  • To differentiate the clinical presentation of NSAID-induced nephritis from antibiotic-induced nephritis.
  • To highlight the demographic and clinical characteristics of NSAID-induced tubulointerstitial disease.
  • To address the uncertainty surrounding the efficacy of steroid treatment for NSAID-induced acute tubulointerstitial nephritis.

Main Methods:

  • Comparative clinical presentation analysis.
  • Review of demographic factors in NSAID-associated tubulointerstitial disease.

Main Results:

  • NSAID-induced nephritis commonly features proteinuria.
  • Antibiotic-related nephritis is more frequently associated with eosinophilia, eosinophiluria, fever, and rash.
  • NSAID-induced tubulointerstitial disease affects women more than men and is more prevalent in the elderly.

Conclusions:

  • Clinical presentation can help distinguish NSAID-induced nephritis from antibiotic-induced nephritis.
  • NSAID-induced acute tubulointerstitial nephritis has specific demographic associations.
  • The effectiveness of steroid therapy for NSAID-induced acute tubulointerstitial nephritis requires further investigation through prospective studies.

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