Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pathophysiology of the atherogenic process.

C J Schwartz1, J L Kelley, R M Nerem

  • 1Department of Pathology, University of Texas Health Science Center, San Antonio 78284-7750.

The American Journal of Cardiology
|October 3, 1989
PubMed
Summary

Atherosclerosis involves inflammation and arterial wall healing. Oxidative modification of low-density lipoprotein (LDL) drives foam cell formation, but antioxidants like probucol may inhibit this process.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Observation of In-Ice Askaryan Radiation from High-Energy Cosmic Rays.

Physical review letters·2026
Same author

Evidence for a Spectral Break or Curvature in the Spectrum of Astrophysical Neutrinos from 5 TeV to 10 PeV.

Physical review letters·2026
Same author

Search for Extremely-High-Energy Neutrinos and First Constraints on the Ultrahigh-Energy Cosmic-Ray Proton Fraction with IceCube.

Physical review letters·2025
Same author

Measurement of Atmospheric Neutrino Oscillation Parameters Using Convolutional Neural Networks with 9.3 Years of Data in IceCube DeepCore.

Physical review letters·2025
Same author

Search for an eV-Scale Sterile Neutrino Using Improved High-Energy ν_{μ} Event Reconstruction in IceCube.

Physical review letters·2024
Same author

Observation of Seven Astrophysical Tau Neutrino Candidates with IceCube.

Physical review letters·2024

Area of Science:

  • Cardiovascular Science
  • Pathophysiology
  • Inflammation Biology

Background:

  • Atherosclerosis is a complex inflammatory disease involving arterial wall responses to injury within a hyperlipidemic environment.
  • Understanding the multifactorial pathophysiology of atherogenesis is crucial for developing effective treatments.

Purpose of the Study:

  • To review key aspects of atherogenesis, focusing on hemodynamic stresses, monocyte recruitment, macrophage scavenger receptor pathways, and lipoprotein modification.
  • To highlight the role of oxidized low-density lipoprotein (LDL) in foam cell formation and plaque development.
  • To discuss the potential of antioxidant therapy in mitigating atherosclerosis.

Main Methods:

  • Review of existing literature on the pathophysiology of atherosclerosis.

Related Experiment Videos

  • Discussion of the influence of shear stress on endothelial cells.
  • Analysis of monocyte recruitment mechanisms and macrophage scavenger receptor pathways.
  • Examination of lipoprotein modification, particularly LDL oxidation.

    • Main Results:

    • Hemodynamic shear stress influences endothelial cell properties and lesion development.
    • Monocyte recruitment to the intima involves chemoattractants like oxidized LDL.
    • Macrophage scavenger receptors mediate the uptake of modified LDL, leading to foam cell formation.
    • Oxidative modification of LDL is a key driver of foam cell formation and plaque progression.

    Conclusions:

    • Atherogenesis is an inflammatory process significantly influenced by hemodynamic factors and lipoprotein metabolism.
    • Oxidized LDL uptake via scavenger receptors is a critical, non-down-regulating mechanism in foam cell formation.
    • The antioxidant probucol demonstrates potential in retarding atherogenesis by preventing LDL oxidation, independent of cholesterol levels.