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Related Concept Videos

Types of RNA01:20

Types of RNA

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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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Types of RNA01:23

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Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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Types of RNA01:23

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lncRNA - Long Non-coding RNAs02:39

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Genomic variations in non-coding RNAs: Structure, function and regulation.

Deeksha Bhartiya1, Vinod Scaria1

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This summary is machine-generated.

Recent advances illuminate how variations in non-coding RNAs (ncRNAs) impact human traits and diseases. Understanding these functional variations is key to deciphering complex genetic links to health and illness.

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Area of Science:

  • Genomics
  • Molecular Biology
  • Bioinformatics

Background:

  • Significant progress in understanding human variations and their links to traits/diseases.
  • High-resolution human transcriptome maps and discovery of non-protein coding RNAs have revolutionized functional variation studies.
  • Functional variations in non-coding RNAs (ncRNAs), including microRNAs, snoRNAs, and lncRNAs, are increasingly reported.

Purpose of the Study:

  • To review the current understanding of functional variations in non-coding RNAs.
  • To provide a conceptual framework for how variations affect ncRNA sequence, structure, and function.
  • To highlight the implications of ncRNA variations in human traits and diseases.

Main Methods:

  • Literature review of recent studies on non-coding RNA variations.
  • Conceptual analysis of the relationship between sequence, structure, and function in ncRNAs.
  • Synthesis of current knowledge on trait/disease-associated ncRNA variations.

Main Results:

  • Variations in ncRNAs can alter their sequence and structure, leading to functional consequences.
  • Understanding ncRNA functionality is crucial for interpreting the impact of genetic variations.
  • A growing body of evidence links ncRNA variations to human traits and diseases.

Conclusions:

  • The study provides a conceptual outline for understanding how genetic variations impact non-coding RNA function.
  • Further research into ncRNA functionalities is essential for fully grasping their role in human health and disease.
  • Advances in genomics offer new insights into the functional relevance of non-coding RNA variations.