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Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
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Is there a risk of permanent renal dysfunction after primary total hip and knee joint replacements?

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Updated: Mar 26, 2026

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
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Risk factors for renal dysfunction after total knee joint replacement.

Basim K Hassan, Arne Sahlström, Ram B Dessau

    Acta Orthopaedica Belgica
    |January 22, 2016
    PubMed
    Summary

    Major surgery, like knee replacement, can cause kidney dysfunction. Advanced age, low blood pressure, hypertension, and general anesthesia are key risk factors for this complication.

    Area of Science:

    • Nephrology
    • Orthopedic Surgery
    • Anesthesiology

    Background:

    • Renal injury and dysfunction are significant complications following major surgical procedures.
    • These complications can lead to increased patient morbidity and mortality.
    • Identifying risk factors for renal dysfunction after total knee replacement is crucial for patient management.

    Purpose of the Study:

    • To identify potential risk factors associated with renal dysfunction after total knee joint replacement surgery.

    Main Methods:

    • A retrospective study analyzed 702 primary knee joint replacements performed between January 2009 and December 2012.
    • Postoperative renal injury was defined by increased serum creatinine, assessed using RIFLE criteria.
    • Statistical analysis was performed to identify significant risk factors.

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    Main Results:

    • 9.7% of patients (63/702) experienced moderate to severe postoperative renal dysfunction.
    • 1.2% of patients (8/702) developed severe and permanent renal impairment.
    • Significant risk factors included advanced age, low intraoperative blood pressure, hypertension, general anesthesia, and prophylactic dicloxacillin.
    • Male gender and Body Mass Index (BMI) were independent risk factors for increased postoperative serum creatinine.

    Conclusions:

    • Advanced age, hypotension, hypertension, general anesthesia, and dicloxacillin increase the risk of renal dysfunction after total knee replacement.
    • Male gender and BMI are independent predictors of postoperative renal function decline.
    • Further research and preventative strategies are warranted to mitigate these risks.