Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Rationale for cholesterol lowering.

R J Havel1

  • 1Cardiovascular Research Institute, University of California, San Francisco 94143-0130.

The American Journal of Medicine
|October 16, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

LIPID TRANSPORT.

A listing of research in the cardiovascular field·2014
Same author

Human apoC-IV: isolation, characterization, and immunochemical quantification in plasma and plasma lipoproteins.

Journal of lipid research·2003
Same author

Sources and properties of triglyceride-rich lipoproteins containing apoB-48 and apoB-100 in postprandial blood plasma of patients with primary combined hyperlipidemia.

Journal of lipid research·2002
Same author

Remnant lipoproteins as therapeutic targets.

Current opinion in lipidology·2000
Same author

Hyperlipidemia: diagnostic and therapeutic perspectives.

The Journal of clinical endocrinology and metabolism·2000
Same author

Genetic underpinnings of LDL size and density: a role for hepatic lipase?

The American journal of clinical nutrition·2000
Same journal

GLP-1 Receptor Agonists and Age-related Macular Degeneration Risk in Diabetes or Non-diabetic Obesity: A Retrospective Cohort Study.

The American journal of medicine·2026
Same journal

Marijuana Use and Acute Myocardial Infarction: Mechanistic Insights, Clinical Implications, and Emerging Challenges.

The American journal of medicine·2026
Same journal

Cave Canem - Beware of the Dog.

The American journal of medicine·2026
Same journal

Risk Factors for 30-day Hospital Readmission After Hospital-at-Home Treatment of Acute Pyelonephritis.

The American journal of medicine·2026
Same journal

Mesenteric Panniculitis.

The American journal of medicine·2026
Same journal

Hypercalcemia and hyperferritinemia in a patient with Graves' disease disease.

The American journal of medicine·2026
See all related articles

Lowering cholesterol levels is crucial for preventing atherosclerosis. New research and effective drugs support broad clinical application of cholesterol-lowering strategies to reduce cardiovascular disease.

Area of Science:

  • Cardiovascular Research
  • Clinical Trials
  • Genetics

Background:

  • Cholesterol management strategies are informed by evidence from epidemiology, pathology, clinical medicine, genetics, and trials.
  • Growing knowledge of lipoprotein pathogenicity and clinical trial outcomes fuels interest in cholesterol lowering.
  • New pharmacological agents and combinations offer effective ways to reduce blood cholesterol levels.

Purpose of the Study:

  • To review current evidence supporting cholesterol-lowering strategies.
  • To highlight advancements in understanding lipoprotein roles in atherosclerosis.
  • To emphasize the translation of research findings into clinical practice.

Main Methods:

  • Synthesis of evidence from five research areas: epidemiology, experimental pathology, clinical medicine, clinical genetics, and clinical trials.

Related Experiment Videos

  • Review of recent clinical trial data on cholesterol-lowering interventions.
  • Analysis of emerging research on triglyceride-rich and high-density lipoproteins.

    • Main Results:

    • Clinical trials demonstrate that cholesterol-lowering interventions reduce atherosclerosis progression and clinical events.
    • New drugs and drug combinations effectively lower blood levels of atherogenic lipoproteins.
    • Ongoing research into specific lipoprotein species may expand therapeutic options.

    Conclusions:

    • Sufficient evidence supports a widespread clinical effort to lower cholesterol.
    • Translating current knowledge into practice is warranted to combat atherosclerotic disease.
    • Further research into lipoprotein metabolism may refine future interventions.