Related Experiment Video
Updated: Feb 26, 2026

Author Spotlight: Microbial Control and Monitoring Strategies for Cleanroom Environments and Cellular Therapies
Published on: March 17, 2023
Impact of CLSI Breakpoint Changes on Microbiology Laboratories and Antimicrobial Stewardship Programs
Emily L Heil1, J Kristie Johnson2
1Department of Pharmacy, University of Maryland Medical Center, Baltimore, Maryland, USA.
Abstract:
In 2010, the Clinical and Laboratory Standards Institute (CLSI) lowered the MIC breakpoints for many beta-lactam antibiotics to enhance detection of known resistance amongEnterobacteriaceae The decision to implement these new breakpoints, including the changes announced in both 2010 and 2014, can have a significant impact on both microbiology laboratories and antimicrobial stewardship programs. In this commentary, we discuss the changes and how implementation of these updated CLSI breakpoints requires partnership between antimicrobial stewardship programs and the microbiology laboratory, including data on the impact that the changes had on antibiotic usage at our own institution.
More Related Videos
12:03Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method
Published on: April 18, 2019
11:17Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
Related Concept Videos
Key Techniques in Microbiology
Urine Studies II: Urine Culture and Sensitivity Test
Antimicrobial Effectiveness
Modern Molecular Taxonomy