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The DNA damage-induced cell death response: a roadmap to kill cancer cells

Sonja Matt1, Thomas G Hofmann2

  • 1German Cancer Research Center (dkfz), Cellular Senescence Group, DKFZ-ZMBH Alliance, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.

Cellular and Molecular Life Sciences : CMLS
|January 22, 2016
PubMed

Insights

Cells resisting DNA damage-induced death can lead to cancer and treatment resistance. Understanding these cell death pathways, including apoptosis and necroptosis, is key for developing new therapies targeting cancer.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Oncology

Background:

  • Cellular resistance to DNA damage-induced death contributes to cancer development and treatment failure.
  • Identifying the molecular mechanisms of cell death is crucial for therapeutic strategies.

Purpose of the Study:

  • To review the signaling pathways involved in DNA damage-induced cell death.
  • To highlight key molecular players and mechanisms in apoptosis and necroptosis.

Main Methods:

  • Literature review of signaling pathways.
  • Analysis of molecular mechanisms in cell death induction.

Main Results:

  • DNA damage triggers cell death pathways like apoptosis and necroptosis when repair fails.
  • These pathways involve nuclear, mitochondrial, and plasma membrane molecules.
  • Resistance to cell death is a hallmark of cancer and treatment resistance.

Conclusions:

  • Understanding DNA damage-induced cell death pathways is vital for cancer therapy.
  • Targeting these pathways offers potential for overcoming radio- and chemoresistance.
Keywords:
ATMATRAdriamycinAxinBAXCancer therapyCaspase 2Chk1Chk2DoxorubicinFOXO3HIPK2Hippo pathwayIonizing radiationMLKLPIDDPMLPUMAPin1RIPK1RIPK3SUMOXAF1Yap1c-Ablp53p53 Serine 46p73

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