Related Experiment Video

Updated: Mar 26, 2026

High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart
11:50

High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart

Published on: July 9, 2010

24.8K

Comparison of Left Ventricular Contractile Abnormalities in Stress-Induced Cardiomyopathy versus Obstructive Coronary

Alexandros Briasoulis1, Karolina Marinescu1, Marian Mocanu1

  • 1Division of Cardiology, Detroit Medical Center, Wayne State University, Detroit, Michigan.

Echocardiography (Mount Kisco, N.Y.)
|January 22, 2016
PubMed

Insights

Takotsubo cardiomyopathy (TC) and acute myocardial infarction (AMI) show similar impairments in left ventricular (LV) strain. Two-dimensional strain imaging can help distinguish between TC patterns.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Cardiomyopathy Research

Background:

  • Limited data exists on left ventricular (LV) strain profiles in takotsubo cardiomyopathy (TC) compared to obstructive coronary artery disease (CAD).
  • Investigating regional and global LV longitudinal strain in TC patients is crucial.

Purpose of the Study:

  • To compare regional and global LV longitudinal strain in patients with TC versus acute cardiomyopathy (ACM) due to severe obstructive coronary artery disease.
  • To utilize two-dimensional strain imaging (2DS) for this comparison.

Main Methods:

  • Transthoracic echocardiography was performed on 34 TC patients, 24 ACM patients, and 30 healthy controls.
  • Segmental longitudinal strain was measured using EchoInsight Epsilon software.
  • Left ventricular global longitudinal strain (GLS) was calculated by averaging segmental wall strains.

Main Results:

  • Both TC and ACM groups showed significantly impaired systolic and diastolic function compared to controls.
  • LV global and segmental systolic strain were significantly attenuated in TC and ACM patients versus controls (P < 0.001).
  • LV basal segmental longitudinal strain was higher in TC patients than ACM patients (P = 0.02).
  • Global and apical segmental strain differentiated mid-ventricular from apical TC variants (P = 0.001).

Conclusions:

  • Longitudinal LV strain parameters are similarly impaired in TC and ACM patients.
  • Two-dimensional LV strain parameters can aid in differentiating between TC patterns.
Abstract

Keywords:
speckle-tracking imagingstrain imagingstress-induced cardiomyopathy

More Related Videos

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography06:34

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Published on: October 28, 2020

4.8K
Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice12:12

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice

Published on: February 14, 2017

16.9K

Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
687
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
744
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
414
Imaging Studies for Cardiovascular System II:Types of Echocardiography01:20

Imaging Studies for Cardiovascular System II:Types of Echocardiography

Echocardiography plays a role in assessing cardiac health and detecting heart conditions, with various types providing critical insights for diagnosis and treatment.
Types of Echocardiography
Transthoracic Echocardiography (TTE)
TTE is the most common type of echocardiogram which involves placing a transducer on the patient's chest, emitting sound waves to create heart images. TTE is invaluable for evaluating the heart's size, structure, and motion, making it particularly useful for...
836
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
425