Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

8.9K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
8.9K
Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

6.5K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
6.5K
The Thyroid Gland01:23

The Thyroid Gland

8.6K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
8.6K
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

1.0K
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
1.0K
Heart Failure I: Introduction01:27

Heart Failure I: Introduction

1.2K
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
1.2K
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

840
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
840

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of Radioiodine on the Nasolacrimal System.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·2022
Same author

Thyroid Abnormalities in Heart Failure.

Cardiology clinics·2022
Same author

Hypothyroid Symptoms in Levothyroxine-Treated Patients.

Innovations in pharmacy·2021
Same author

Thyroid Abnormalities in Heart Failure.

Heart failure clinics·2019
Same author

Assessment of the Adequacy of Thyroid Hormone Replacement Therapy in Hypothyroidism.

Frontiers in endocrinology·2019
Same author

Thyroid Hormones and Cardiovascular Function and Diseases.

Journal of the American College of Cardiology·2018
Same journal

Implantable cardioverter-defibrillator in cardiac sarcoidosis: A propensity-score matched analysis.

Current problems in cardiology·2026
Same journal

Arterial Stiffness in Heart Failure with Preserved Ejection Fraction: is this a new Predisposing Factor?

Current problems in cardiology·2026
Same journal

The future of cardiovascular training: Bridging global disparities and building a hybrid model for equity in care.

Current problems in cardiology·2026
Same journal

Disparities in healthcare access and treatment outcomes for patients with chronic limb-threatening ischemia.

Current problems in cardiology·2026
Same journal

Diagnostic and prognostic value of coronary computed tomography angiography and high-risk plaque assessment in acute coronary syndrome.

Current problems in cardiology·2026
Same journal

Prognostic value of albuminuria in heart failure with preserved ejection fraction: A systematic review.

Current problems in cardiology·2026
See all related articles

Related Experiment Video

Updated: Mar 26, 2026

Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis
05:41

Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis

Published on: February 9, 2024

1.2K

Thyroid Disease and the Heart.

Irwin Klein, Sara Danzi

    Current Problems in Cardiology
    |January 22, 2016
    PubMed
    Summary
    This summary is machine-generated.

    Thyroid hormones significantly impact heart function, with thyroid disease causing notable cardiac symptoms. Understanding thyroid hormone

    More Related Videos

    Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
    04:14

    Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model

    Published on: October 6, 2023

    1.4K
    Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse
    04:05

    Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse

    Published on: October 6, 2023

    830

    Related Experiment Videos

    Last Updated: Mar 26, 2026

    Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis
    05:41

    Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis

    Published on: February 9, 2024

    1.2K
    Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
    04:14

    Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model

    Published on: October 6, 2023

    1.4K
    Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse
    04:05

    Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse

    Published on: October 6, 2023

    830

    Area of Science:

    • Cardiology and Endocrinology
    • Molecular and Cellular Biology

    Background:

    • Thyroid hormones are crucial for cardiac function.
    • Thyroid disease commonly presents with cardiac manifestations.
    • Understanding thyroid hormone's molecular and cellular actions is key.

    Purpose of the Study:

    • To explore the relationship between thyroid hormones and cardiac function.
    • To examine the molecular and cellular effects of thyroid hormone on the heart.
    • To discuss special considerations for statin and amiodarone therapy in heart disease patients with thyroid alterations.

    Main Methods:

    • Review of existing literature on thyroid hormone metabolism and cardiac effects.
    • Analysis of molecular and cellular mechanisms of thyroid hormone action.
    • Discussion of pharmacological interactions and therapeutic considerations.

    Main Results:

    • Thyroid hormones exert profound effects on the cardiovascular system.
    • Both hypothyroidism and hyperthyroidism lead to distinct cardiac alterations.
    • Statin and amiodarone therapies require careful consideration due to their impact on thyroid hormone metabolism.

    Conclusions:

    • Thyroid hormone levels are intrinsically linked to cardiovascular health.
    • Clinical management of thyroid disease must address cardiac implications.
    • Further research into drug interactions is essential for optimizing patient care.