Food effects on the nighttime pharmacokinetics of Theo-Dur tablets

A randomized crossover study demonstrated major food effects on the pharmacokinetics of Theo-Dur, two 200-mg theophylline anhydrous sustained-release tablets, as an evening dose. These effects included a higher maximum serum theophylline level and relatively prolonged delay in drug absorption, both significant. The findings, which showed marked individual variation, could be clinically important for patients receiving evening medication.