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Updated: Aug 2, 2026

Synthesis, Cellular Delivery and In vivo Application of Dendrimer-based pH Sensors
Published on: September 10, 2013
Dynamic nuclear polarization of biocompatible (13)C-enriched carbonates for in vivo pH imaging
D E Korenchan1, R R Flavell2, C Baligand2
1UC Berkeley-UCSF Graduate Program in Bioengineering, University of California, Berkeley and University of California, San Francisco, California, USA. john.kurhanewicz@ucsf.edu and Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA. david.m.wilson@ucsf.edu.
Abstract:
A hyperpolarization technique using carbonate precursors of biocompatible molecules was found to yield high concentrations of hyperpolarized (13)C bicarbonate in solution. This approach enabled large signal gains for low-toxicity hyperpolarized (13)C pH imaging in a phantom and in vivo in a murine model of prostate cancer.
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