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Pathologic Features of Colorectal Inflammatory Polyps in Miniature Dachshunds.

E Uchida¹, J K Chambers¹, K Nakashima²

¹Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, University of Tokyo, Tokyo, Japan.

Veterinary Pathology

|January 22, 2016

Summary

Colorectal inflammatory polyps predominantly affect Miniature Dachshunds, showing distinct histopathologic features and stages. These polyps involve hyperplastic goblet cells positive for cytokeratin 20 (CK20) and express higher cyclooxygenase 2 and fibroblast growth factor 2.

Keywords:

COX-2 colorectal polyp inflammatory polyp miniature dachshund

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Area of Science:

Veterinary Pathology
Gastroenterology
Oncology

Background:

Colorectal polyps in dogs can be proliferative or inflammatory.
Miniature Dachshunds may have a breed predisposition to specific colorectal lesions.
Understanding histopathologic differences is crucial for accurate diagnosis and prognosis.

Purpose of the Study:

To compare histopathologic features of colorectal inflammatory polyps with adenomas and adenocarcinomas in dogs.
To identify specific characteristics of inflammatory polyps in Miniature Dachshunds.
To investigate the expression of key molecular markers in different colorectal lesions.

Main Methods:

Histopathologic classification of 53 colorectal polypoid lesions (26 inflammatory polyps, 18 adenomas, 9 adenocarcinomas).
Staging of inflammatory polyps based on epithelial composition and inflammatory infiltrate.
Immunohistochemical analysis for cytokeratin 20 (CK20), beta-catenin, cyclooxygenase 2 (COX2), and fibroblast growth factor 2 (FGF2).

Main Results:

All 26 inflammatory polyps occurred in Miniature Dachshunds, indicating breed predilection.
Inflammatory polyps showed 3 stages with increasing inflammation, mucus, granulation, and occasional osteoid tissue.
Hyperplastic goblet cells in inflammatory polyps were CK20-positive, unlike dysplastic/tumor cells (CK20-negative).
CK20-negative cells showed beta-catenin immunoreactivity.
Inflammatory polyps exhibited significantly higher COX2 and FGF2 expression compared to adenomas and adenocarcinomas.

Conclusions:

Colorectal inflammatory polyps have distinct histopathologic features and a strong predilection for Miniature Dachshunds.
CK20 expression differentiates hyperplastic goblet cells from dysplastic/neoplastic cells.
Elevated COX2 and FGF2 suggest involvement of the arachidonate cascade in inflammatory polyp development.