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Determination of iNOS-2087A>G Polymorphism in Acute Pancreatitis Patients
V Pădureanu1, Ioana StreaȚă1, M Ioana1
1Research Center of Gastroenterology and Hepatology, Craiova, ROMANIA.
Purpose:
To determine whether single nucleotide polymorphism (SNP) of inducible nitric oxide synthase (iNOS) is involved in susceptibility for acute pancreatitis.
Material And Methods:
Genomic DNA was extracted from blood samples collected from cases of acute pancreatitis (n=110) and normal population controls frequency matched for age and sex (n=232). iNOS - 2087A>G polymorphism was genotyped using TaqMan allelic discrimination assays. The association of the genetic polymorphism with clinical and pathological data of the patients was evaluated.
Results:
We have found no significant statistical association between this polymorphism and an increased risk of developing acute pancreatitis.
Conclusion:
In Romanian population, the risk of developing acute pancreatitis is not increased by the presence of iNOS-2087A>G polymorphism.
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