Related Experiment Video
Updated: Mar 26, 2026

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
Published on: May 10, 2024
Atypical Presentation of Eosinophilic Fasciitis with Pitting Edema
Chih-Wei Chang1, Matthew S Lau1
1John A. Burns School of Medicine, University of Hawai'i, Honolulu, HI (C-WC).
Abstract:
Eosinophilic fasciitis (EF) is a rare condition involving inflammation of the fascia and peripheral eosinophilia of unknown etiology leading to tissue fibrosis. Clinical presentation includes peripheral eosinophilia, symmetrical skin thickening with subcutaneous tissue induration of the extremities and rashes developing acutely over a period of days to weeks. An unusual feature of EF is the presence of symmetric pitting edema presumed to be secondary to vascular leakage. This is a case of eosinophilic fasciitis presenting in atypical fashion with pitting peripheral edema in addition to the classic symptoms.
Related Concept Videos
Endocarditis II: Clinical Features of Infective Endocarditis
Nephrotic Syndrome I : Introduction
Assessment of the Cardiovascular System III: Palpation
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
Atypical Pneumonia
Heart Failure III: Clinical Manifestations

