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Trichosporon fungemia in a pediatric patient with acute lymphoblastic leukemia

Luke Maxfield1, Juliana J Matthews1, David Ryan Ambrosetti1

  • 15151 N. Ninth Avenue, Pensacola, FL 32504, United States.

Idcases
|January 22, 2016
PubMed

Insights

Trichosporon fungemia is a dangerous infection in immunocompromised patients. This case highlights the challenges in treating pediatric trichosporonosis, emphasizing the need for continuous antifungal therapy.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Pediatric Medicine

Background:

  • Trichosporon fungemia is an opportunistic infection with increasing incidence.
  • Invasive disease predominantly affects immunocompromised individuals, especially neutropenic adults with hematological malignancies.
  • Pediatric cases are uncommon but can be severe.

Purpose of the Study:

  • To report a case of disseminated trichosporonosis in a pediatric patient.
  • To illustrate the therapeutic challenges and the importance of sustained antifungal treatment in pediatric trichosporonosis.

Main Methods:

  • Case report of a pediatric patient with disseminated trichosporonosis.
  • Documented treatment course including micafungin, voriconazole, and amphotericin B.
  • Clinical and microbiological monitoring during antifungal therapy.

Main Results:

  • Disseminated trichosporonosis progressed despite treatment with micafungin.
  • The patient received sequential antifungal agents, including voriconazole and amphotericin B.
  • Treatment failure indicated the complexity of managing this infection in a pediatric host.

Conclusions:

  • Pediatric trichosporonosis can be difficult to treat and may progress during antifungal therapy.
  • Prolonged and continuous antifungal treatment is crucial for successful outcomes.
  • This case underscores the need for careful monitoring and adaptable treatment strategies for invasive fungal infections in children.
Keywords:
Acute lymphoblastic leukemiaAntifungal resistanceFungemiaTrichosporon

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