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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Tumor Progression02:07

Tumor Progression

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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Related Experiment Video

Updated: Jan 6, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
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A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

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[Recent advancements in prostate cancer basic research].

Takahiro Inoue, Osamu Ogawa

    Nihon Rinsho. Japanese Journal of Clinical Medicine
    |January 23, 2016
    PubMed
    Summary
    This summary is machine-generated.

    New hormonal therapies for prostate cancer (PCa) have emerged, driven by research into castration-resistance. Advanced sequencing and mass spectrometry aid personalized PCa treatment and understanding resistance mechanisms.

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    Area of Science:

    • Oncology
    • Genetics
    • Biochemistry

    Context:

    • Prostate cancer (PCa) research has identified mechanisms driving castration-resistance.
    • The introduction of novel hormonal agents like abiraterone acetate and enzalutamide marks progress in PCa treatment.
    • Next-generation sequencing (NGS) enhances understanding of PCa biology, paving the way for personalized medicine.

    Purpose:

    • To review the current knowledge of the prostate cancer mutational landscape using NGS.
    • To discuss the advancements in sensitive analytical techniques, including imaging mass spectrometry.
    • To summarize the mechanisms underlying resistance to new hormonal therapies in PCa.

    Summary:

    • Recent basic research has elucidated mechanisms of castration-resistant prostate cancer (PCa), leading to new hormonal therapies (abiraterone acetate, enzalutamide).
    • Next-generation sequencing (NGS) has significantly improved the understanding of PCa biology and supports a personalized treatment approach.
    • This review covers the PCa mutational landscape via NGS, discusses advanced mass spectrometry techniques, and summarizes resistance mechanisms to novel hormonal agents.

    Impact:

    • Advances in understanding PCa biology and resistance mechanisms can lead to more effective, personalized treatment strategies.
    • Improved analytical techniques like imaging mass spectrometry offer enhanced detection and characterization of PCa.
    • This knowledge contributes to overcoming treatment resistance and improving outcomes for prostate cancer patients.