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Related Concept Videos

Treatment Resistant Cancers02:56

Treatment Resistant Cancers

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Cancer Therapies02:49

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Combination Therapies and Personalized Medicine02:50

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance
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[Multimodality therapy for high-risk prostate cancer].

Shingo Hatakeyama, Chikara Ohyama

    Nihon Rinsho. Japanese Journal of Clinical Medicine
    |January 23, 2016
    PubMed
    Summary

    High-risk prostate cancer management requires a multimodal strategy. Combining treatments like androgen deprivation therapy (ADT), radiotherapy, and chemotherapy improves outcomes, especially with advances in detecting spread and targeted therapies.

    Area of Science:

    • Oncology
    • Urology
    • Cancer Research

    Context:

    • High-risk prostate cancer necessitates tailored treatment strategies.
    • The role of androgen deprivation therapy (ADT) around prostatectomy requires further definition.
    • Pelvic lymph node dissection during radical prostatectomy remains a subject of debate.

    Purpose:

    • To review current multimodal treatment approaches for high-risk prostate cancer.
    • To evaluate the efficacy of combining radiotherapy with ADT and docetaxel.
    • To explore the impact of novel diagnostic and therapeutic strategies.

    Summary:

    • Radical prostatectomy with adjuvant or salvage therapy offers high long-term survival in select patients.
    • Recent trials show improved outcomes with combined radiotherapy, ADT, and docetaxel for high-risk prostate cancer.

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  • Innovations in oligometastasis detection and systemic therapies combined with local treatments are advancing care.

    • Impact:

    • Optimized multimodal treatment plans can significantly improve cancer control and survival rates.
    • Advances in early detection of cancer spread and targeted therapies promise better patient outcomes.
    • Personalized treatment approaches are crucial for managing high-risk prostate cancer effectively.