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Updated: Mar 26, 2026
Cell Labeling and Targeting with Superparamagnetic Iron Oxide Nanoparticles
Published on: October 19, 2015
One-step ligand exchange and switching from hydrophobic to water-stable hydrophilic superparamagnetic iron oxide
Katalin V Korpany1, Cristina Mottillo1, Jill Bachelder1
1Department of Chemistry, McGill University, 801 Sherbrooke St. W., H3A 0B8 Montreal, Canada. amy.blum@mcgill.ca tomislav.friscic@mcgill.ca.
Abstract:
We describe a simple, rapid methodology for the synthesis of water-stable iron oxide nanoparticles (IONPs) compatible with a variety of aqueous buffers, based on mechanochemical milling exchange of covalently bound surface ligands on pre-fabricated oleic acid-protected IONPs. Application of milling for IONP ligand exchange eliminates steps required for transforming hydrophobic into negatively charged, water-soluble superparamagnetic IONPs.
