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Inflammation and activity augment brain-derived neurotrophic factor peripheral release.

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  • 1Department of Physiology and Biophysics, Virginia Commonwealth University, School of Medicine, Richmond, VA, United States.

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Summary
This summary is machine-generated.

Peripheral release of brain-derived neurotrophic factor (BDNF) from primary afferent neurons in dorsal root ganglia (DRG) was investigated. BDNF is released to nerve terminals in response to depolarization and visceral inflammation, impacting neurogenic inflammation.

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Area of Science:

  • Neuroscience
  • Cell Biology
  • Neuroinflammation

Background:

  • Brain-derived neurotrophic factor (BDNF) is vital for central nervous system synaptic function.
  • Peripheral BDNF release from primary afferent neurons remains largely uncharacterized.

Purpose of the Study:

  • To investigate BDNF synthesis and release from primary afferent neurons in peripheral tissues.
  • To explore the role of BDNF in visceral inflammation and neurogenic inflammatory states.

Main Methods:

  • Utilized two-compartmented cultures of dorsal root ganglia (DRG) neurons.
  • Stimulated neurons with potassium (K+) depolarization and visceral inflammation (urinary bladder).
  • Assessed BDNF and pro-BDNF levels via immunoreactivity, and receptor expression (TrkB, p75) and activity (TrkB phosphorylation) in inflamed bladders. Analyzed proliferation marker Ki67.

Main Results:

  • BDNF is synthesized and released from rat DRG neurons to spinal nerve terminals upon depolarization.
  • Visceral inflammation significantly increases spontaneous BDNF release to peripheral nerve terminals.
  • Elevated BDNF and pro-BDNF levels, increased TrkB/p75 expression, and enhanced TrkB activity were observed in inflamed bladders, correlating with increased Ki67 proliferation marker.

Conclusions:

  • Primary afferent neurons release BDNF peripherally, influencing neurogenic inflammation.
  • Peripheral BDNF release may contribute to pro-proliferative effects in inflamed visceral organs.
  • This study highlights a novel role for peripheral BDNF in inflammatory conditions.