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Prostatic complications of testosterone replacement therapy.

J A Jackson¹, J Waxman, A M Spiekerman

¹Department of Medicine, Scott and White Clinic, Scott and White Memorial Hospital, Temple.

Archives of Internal Medicine

|October 1, 1989

Summary

Testosterone replacement therapy may increase risks of prostate disease, including cancer, in men over 50. Regular prostate screening is recommended during androgen replacement therapy for early detection.

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Area of Science:

Urology
Endocrinology
Oncology

Background:

Testosterone replacement therapy (TRT) is increasingly used for hypogonadism.
Potential prostatic complications of TRT require further clinical investigation.

Observation:

Three hypogonadal men developed prostatic disease, including adenocarcinoma in two, during TRT.
This highlights a potential link between TRT and prostate pathology.

Findings:

Literature review supports surveillance for early prostate cancer in men over 50 undergoing TRT.
Prostate-specific antigen (PSA) testing, digital rectal examination (DRE), transrectal sonography, and biopsy are key surveillance tools.

Implications:

Selective screening is crucial for older men on androgen replacement therapy.

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Early detection of prostate cancer during TRT can improve patient outcomes.

Further research into TRT's long-term effects on the prostate is warranted.