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The effect of oxygen saturation targeting on retinal blood vessel growth using retinal image data from the BOOST-II

R B R Moreton1, B W Fleck2, A R Fielder3

  • 1Academic Foundation Programme Trainee, Edinburgh, UK.

Eye (London, England)
|January 23, 2016
PubMed

Insights

Higher oxygen saturation (91-95%) in preterm infants showed a trend toward reduced retinal blood vessel growth compared to lower targets (85-89%). This finding suggests careful oxygen management is crucial for preventing retinopathy of prematurity complications.

Area of Science:

  • Ophthalmology
  • Neonatology
  • Pediatric Medicine

Background:

  • Retinopathy of prematurity (ROP) is a significant cause of visual impairment in premature infants.
  • Developing retinal blood vessels in preterm infants are susceptible to abnormal growth patterns.
  • Oxygen saturation (SpO2) levels are a critical factor in neonatal care and ROP development.

Purpose of the Study:

  • To investigate the impact of higher (91-95%) versus lower (85-89%) oxygen saturation targeting on retinal blood vessel growth in preterm infants.
  • To compare temporal and nasal retinal blood vessel extension in relation to different SpO2 targets.

Main Methods:

  • Utilized RetCam images from the BOOST-II UK trial for analysis.
  • Measured distances between the optic disc center and ROP ridge in temporal and nasal retina.
  • Compared retinal blood vessel growth in infants randomized to higher vs. lower SpO2 target groups.

Main Results:

  • Temporal blood vessels naturally extended further than nasal vessels (P<0.0001).
  • A trend towards reduced temporal retinal blood vessel growth was observed in the higher SpO2 target group (P=0.055).
  • Nasal retinal blood vessel growth showed no significant difference between the SpO2 target groups (P=0.38).

Conclusions:

  • Higher oxygen saturation targeting (91-95%) may be associated with decreased retinal blood vessel growth in preterm infants.
  • These findings suggest a potential link between oxygen management strategies and ROP progression.
  • Further research is warranted to confirm these trends and optimize SpO2 targets for ROP prevention.
Abstract

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