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A triazine-based BODIPY trimer as a molecular viscometer.

Sangram L Raut1, Joseph D Kimball1, Rafal Fudala2

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A novel trimeric BODIPY rotor acts as a sensitive molecular rotor, enabling viscosity measurements in various environments. This fluorescent probe is effective in molecular solvents, membranes, and cancer cells.

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Area of Science:

  • Photochemistry
  • Supramolecular Chemistry
  • Biophysical Chemistry

Background:

  • Boron-dipyrromethene (BODIPY) dyes are known for their unique photophysical properties.
  • Molecular rotors are sensitive to their local environment, making them useful for probing viscosity.

Purpose of the Study:

  • To investigate the photophysical behavior of a novel trimeric BODIPY rotor.
  • To evaluate its potential as a fluorescent viscosity sensor.

Main Methods:

  • Steady-state and time-resolved fluorescence spectroscopy.
  • Viscosity measurements in diverse media.

Main Results:

  • The trimeric BODIPY rotor exhibits a high extinction coefficient.
  • Its fluorescence intensity and lifetime correlate with viscosity.
  • Successful application as a viscometer in molecular solvents, membrane-mimicking environments, and cancer cell lines.

Conclusions:

  • The novel trimeric BODIPY rotor demonstrates excellent performance as a fluorescent viscometer.
  • Its sensitivity to microviscosity makes it a valuable tool for biological and chemical sensing applications.