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Updated: Mar 26, 2026

A Mouse Model of Intestinal Partial Obstruction
Published on: March 5, 2018
Large-bowel disease presenting as small-bowel obstruction is associated with a poor prognosis
Jessica L Weaver1, Rebecca E Barnett1, Danielle E Patterson1
1Hiram C. Polk Jr MD Department of Surgery, University of Louisville School of Medicine, 550 South Jackson St, Louisville, KY, 40292, USA; Robley Rex Veterans Affairs Medical Center, 800 Zorn Ave, Louisville, KY, 40206, USA.
Introduction:
Small-bowel obstruction (SBO) is a common cause of admission to the surgical service. On rare occasions, a diagnosed SBO is actually due to large-bowel pathology combined with an incompetent ileocecal valve. The purpose of this study was to investigate this phenomenon.
Methods:
We performed a retrospective medical record review of patients that were admitted with a diagnosis of SBO at University of Louisville hospital and the Veterans Affairs hospitals in Louisville, KY, from 2006 until 2014.
Results:
A total of 498 patients were admitted with SBO during this time period. Forty-one patients were found to have an underlying large-bowel disease. The most common large-bowel pathologies included malignancy (51%), inflammation (15%), and infection (15%). Fifteen (43%) of these patients died during admission; 93% of these were due to either their bowel obstruction or the underlying disease state. This was significantly higher than the general population (9.4% mortality, 6% due to underlying disease).
Conclusions:
Patients that present with SBO due to a large-bowel source have a much higher mortality rate than those that present with other causes. Rapid identification of these patients will allow for more timely and appropriate treatment.
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