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Neutrophils and asthma.

P Boschetto¹, C E Mapp, G Picotti

¹Institute of Occupational Medicine, University of Padua, Italy.

The European Respiratory Journal. Supplement

|June 1, 1989

Summary

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Neutrophils play a role in asthma exacerbations by increasing airway responsiveness. However, they are not implicated in the long-term airway hyperresponsiveness seen in stable asthma patients.

Area of Science:

Respiratory Medicine
Immunology
Cell Biology

Background:

Inflammation is a key feature of asthma, with various immune cells implicated.
Neutrophils are observed in airways during asthma attacks and experimental models.

Purpose of the Study:

To review the role of neutrophils in asthma exacerbations and airway hyperresponsiveness.
To differentiate neutrophil involvement in acute versus chronic asthma.

Main Methods:

Review of existing studies on neutrophils in human and animal asthma models.
Analysis of neutrophil presence and function during spontaneous and induced asthma reactions.

Main Results:

Neutrophil depletion prevents asthma exacerbation effects; repletion restores them.

Related Experiment Videos

Stimulated neutrophil supernatant induces transient airway hyperresponsiveness.

Neutrophils are not elevated in stable asthmatics and do not cause experimental hyperresponsiveness in some animals.

Conclusions:

Neutrophils are likely involved in the transient airway hyperresponsiveness during asthma exacerbations.
Neutrophils do not appear to contribute to the persistent airway hyperresponsiveness in stable asthmatics.