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Updated: Mar 26, 2026

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
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Histopathological Correlates of Global and Segmental Left Ventricular Systolic Dysfunction in Experimental Chronic

Luciano Fonseca Lemos de Oliveira1, Minna Moreira Dias Romano1, Eduardo Elias Vieira de Carvalho1

  • 1Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil (L.F.L.O., M.M.D.R., E.E.V.C., C.S., R.F.J., R.S.C., J.S.S., B.C.M., J.A.M.N., M.V.S.).

Journal of the American Heart Association
|January 23, 2016
PubMed

Insights

In experimental Chagas cardiomyopathy, wall motion abnormalities (WMA) often appear with normal heart function, primarily linked to inflammation, not fibrosis.

Area of Science:

  • Cardiology
  • Parasitology
  • Pathology

Background:

  • Chronic Chagas cardiomyopathy presents with left ventricular wall motion abnormalities (WMA).
  • Early detection of WMA is crucial for understanding disease progression.

Purpose of the Study:

  • Investigate WMA detection in a hamster model of chronic Chagas cardiomyopathy.
  • Correlate WMA with underlying histopathological changes.

Main Methods:

  • Female Syrian hamsters infected with Trypanosoma cruzi.
  • Echocardiography assessed left ventricular systolic function at 6 and 10 months.
  • Histological analysis quantified fibrosis and inflammation in cardiac segments.

Main Results:

  • 29% of infected hamsters showed reduced ejection fraction.
  • Among those with preserved ejection fraction, 33% exhibited segmental WMA.
  • WMA segments had significantly higher inflammation intensity and fibrosis extent compared to normal segments.

Conclusions:

  • Segmental WMA can occur with preserved global systolic function in experimental Chagas cardiomyopathy.
  • Inflammation is the predominant histopathological feature associated with WMA in this model.
Abstract

Keywords:
Chagas heart failureechocardiographypathology

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