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Updated: Mar 26, 2026

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT
Published on: January 7, 2018
[Type B insulin resistance syndrome: 3 cases report and literature review]
Guoqing Yang1, Jingtao Dou, Zhaohui Lyu
1Department of Endocrinology, Chinese PLA General Hospital, Beijing 100853, China.
Objective:
To understand type B insulin resistance syndrome (B-IRS) by reviewing 3 cases from our center and cases from literatures.
Methods:
The clinical characteristics, diagnosis, treatment and follow-up data of the 3 patients with B-IRS were evaluated.
Results:
All the 3 patients were middle-aged women with severe hyperglycemia or paradoxical hypoglycemia. The clinical findings were as follows. (1)B-IRS was associated with several autoimmune diseases such as systemic lupus erythematosus (SLE) and sclerosis. (2) The metabolic abnormalities of B-IRS include weight loss, severe hyperinsulinemia, high level of adiponectin, and low level of insulin-like growth factor type 1(IGF-1) and TG. (3)B-IRS was characterized with nonspecific serological disorders (such as leukopenia, thrombocytopenia and hypoalbuminemia) and changes (decreased complements and elevated IgG and/or IgA), and with specific immunological abnormalities[such as high titer of antinuclear antibody(ANA), positive in anti-SSA, anti-SSB and anti-dsDNA antibodies). Positive in anti-insulin receptor antibody was of diagnostic value but not necessary. (4) Treatments include insulin in combination with immunosuppressive therapy. Patients with H. pylori (Hp) infection may be benefit with eradication therapy.
Conclusions:
B-IRS is rare but not difficult to identify. Treatments include therapy of the underlying diseases and high dose of insulin.
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