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Rethinking Functional Segregation: Gradients of Gene Expression in Area CA1
Georgi Tushev1, Erin M Schuman2
1Scientific Computing, Max Planck Institute for Brain Research, Max von Laue Strasse 4, 60438 Frankfurt am Main, Germany; Synaptic Plasticity, Max Planck Institute for Brain Research, Max von Laue Strasse 4, 60438 Frankfurt am Main, Germany.
Abstract:
An emerging view, based on gene expression patterns, is that discrete cell types occupy different regions in the hippocampus. In this issue of Neuron, Cembrowski et al. (2016) challenge this concept by identifying gradients of gene expression that suggest a molecular continuum of excitatory neurons and provide insights for organizational motifs at hippocampal poles.
