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Serum IL-33 Is Elevated in Children with Asthma and Is Associated with Disease Severity

Sedigheh Bahrami Mahneh1, Masoud Movahedi, Zahra Aryan

  • 1Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

International Archives of Allergy and Immunology
|January 23, 2016
PubMed

Insights

Serum interleukin-33 (IL-33) levels are elevated in children with asthma and correlate with disease severity. This finding highlights IL-33

Area of Science:

  • Immunology
  • Pediatrics
  • Respiratory Medicine

Background:

  • The precise role of Interleukin-33 (IL-33) in asthma pathogenesis remains incompletely elucidated.
  • IL-33, a cytokine belonging to the IL-1 family, is implicated in airway hyperresponsiveness.

Purpose of the Study:

  • To investigate serum IL-33 levels in pediatric asthma patients.
  • To determine the association between serum IL-33 concentrations and asthma severity in children.

Main Methods:

  • An age- and sex-matched case-control study involving 61 children with asthma and 63 healthy controls.
  • Serum IL-33 levels were quantified using Enzyme-Linked Immunosorbent Assay (ELISA).
  • Comparison of IL-33 levels between asthmatic children and controls, and correlation with asthma severity.

Main Results:

  • Serum IL-33 levels were significantly higher in children with asthma compared to healthy controls (p=0.028).
  • A positive correlation was observed between serum IL-33 levels and asthma severity.
  • IL-33 levels increased progressively with asthma severity: mild (9.92 ± 30.26 pg/ml), moderate (13.68 ± 29.27 pg/ml), and severe (31.92 ± 41.45 pg/ml) (p=0.026).

Conclusions:

  • Elevated serum IL-33 is a characteristic finding in children with asthma.
  • Serum IL-33 levels are significantly associated with the severity of childhood asthma.
Abstract

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