Activity-dependent regulation of gene expression in muscle and neuronal cells

In both the central and the peripheral nervous systems, impulse activity regulates the expression of a vast number of genes that code for synaptic proteins, including neuropeptides, enzymes involved in neurotransmitter biosynthesis and degradation, and membrane receptors. In recent years, the mechanisms involved in these regulations became amenable to investigation by the methods of recombinant DNA technology. The first part of this review focuses on the activity-dependent control of nicotinic acetylcholine receptor biosynthesis in vertebrate muscle, a model case for the regulation of synaptic protein biosynthesis at the postsynaptic level. The second part summarizes some examples of neuronal proteins whose biosynthesis is under the control of transsynaptic impulse activity. The first, second, and third intracellular messengers involved in membrane-to-gene signaling are discussed, as are possible posttranscriptional control mechanisms. Finally, models are proposed for a role of neuronal activity in the genesis and stabilization of the synapse.