Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

85
Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
85
Structure-Activity Relationships and Drug Design01:28

Structure-Activity Relationships and Drug Design

2.0K
Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
2.0K
Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

754
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
754
Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules01:18

Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules

403
Bioequivalence in generic drugs, such as tablets and capsules, refers to their pharmaceutical equivalence to the brand-name counterparts. However, for therapeutic equivalence, manufacturers must also consider physical attributes like size, shape, and weight (FDA Guidance for Industry, December 2003). Discrepancies in these aspects could impact patient compliance and cause medication errors. For instance, swallowing difficulties, often experienced with larger tablets or capsules, can lead to...
403
Biopharmaceutical Factors Influencing Drug Product Design: Overview01:22

Biopharmaceutical Factors Influencing Drug Product Design: Overview

429
Rational drug product design integrates knowledge of the drug’s physicochemical properties, formulation components, manufacturing techniques, and intended route of administration. Each factor influences the drug’s performance, including how it is released, absorbed, and eliminated in the body.The physicochemical properties of a drug—such as solubility, stability, and particle size—affect its compatibility with excipients and the choice of dosage form. Excipients, though...
429
Modified-Release Drug Delivery Systems: Influencing Factors01:20

Modified-Release Drug Delivery Systems: Influencing Factors

125
Modified-release drug delivery systems are designed to optimize the therapeutic effect of drugs by minimizing side effects, reducing the dosage required, and controlling drug release to align with pharmacokinetic and pharmacodynamic needs. The system depends on two key factors: the drug's release from the formulation and its movement through the body to the target site. Unlike conventional dosage forms, where absorption is the limiting step, the rate of drug release is the key determinant in...
125

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The association between paramedic service system hospital offload time and response time.

CJEM·2023
Same author

Computed tomography analysis of the anterior ethmoid genu of the frontal recess in non-diseased sinuses.

The Journal of laryngology and otology·2021
Same author

Linkage of Emergency Medical Services and Hospital Data: A Necessary Precursor to Improve Understanding of Outcomes of Prehospital Care.

Prehospital emergency care·2021
Same author

Systemic cytomegalovirus infection complicating ulcerative colitis: a case report and review of the literature.

Postgraduate medical journal·2004
Same author

Stereoselective synthesis of a novel carbocyclic nucleoside.

The Journal of organic chemistry·2001
Same author

Radical mediated ring opening of 1,2-cyclopropanated-D-glycal: unusual formation of S-methylglycosyl-S-methylthiocarbonate.

Carbohydrate letters·2001
Same journal

Comparison of Calcium Phosphate and Zinc Oxide Nanoparticles as Dermal Penetration Enhancers for Albumin.

Indian journal of pharmaceutical sciences·2020
Same journal

Phytochemical Analysis and In vitro Antioxidant Studies of Plumeria obtusa L. Leaves.

Indian journal of pharmaceutical sciences·2016
Same journal

Estimation Based on Emission Wavelength of Dabigatran Etexilate Mesylate in Bulk and Capsule Dosage Form.

Indian journal of pharmaceutical sciences·2016
Same journal

Evaluation of Immunomodulatory Activity of the Alkaloid Fraction of Trichopus zeylanicus Gaertn on Experimental Animals.

Indian journal of pharmaceutical sciences·2016
Same journal

Can Analgesic-abuse Nephropathy is a Fertile Groundfor for Rare Collecting Duct (Bellini Duct) Renal Cell Carcinoma or Merely a Coincidence?

Indian journal of pharmaceutical sciences·2016
Same journal

Sensitivity of Interfibrillar and Subsarcolemmal Mitochondria to Cobalt Chloride-induced Oxidative Stress and Hydrogen Sulfide Treatment.

Indian journal of pharmaceutical sciences·2016
See all related articles

Related Experiment Video

Updated: Mar 26, 2026

Optimization of the Epimedii Folium Mutton-Oil Processing Technology and Testing Its Effect on Zebrafish Embryonic Development
06:00

Optimization of the Epimedii Folium Mutton-Oil Processing Technology and Testing Its Effect on Zebrafish Embryonic Development

Published on: March 17, 2023

954

Design, Development and Optimization of S (-) Atenolol Floating Sustained Release Matrix Tablets Using Surface

P T Gunjal1, M B Shinde1, V S Gharge2

  • 1Formulation and Development Department, Zuventus Healthcare Ltd, T-184 MIDC Bhosari, Pune-411 026, India.

Indian Journal of Pharmaceutical Sciences
|January 23, 2016
PubMed
Summary
This summary is machine-generated.

This study developed floating sustained release matrix tablets for s (-) atenolol using cellulose-based polymers. Optimized tablets demonstrated sustained drug release, offering potential therapeutic advantages over conventional formulations.

Keywords:
Buoyancy timefloating lag timefloating sustained releasehydrophilic polymerss (-) atenololsurface response methodology

More Related Videos

Formation of Dispersible Taohong Siwu Tablets
05:44

Formation of Dispersible Taohong Siwu Tablets

Published on: February 3, 2023

2.2K
Author Spotlight: Optimization of Processing Technology for Tiebangchui with Zanba Based on CRITIC Combined with Box-Behnken Response Surface Method
09:16

Author Spotlight: Optimization of Processing Technology for Tiebangchui with Zanba Based on CRITIC Combined with Box-Behnken Response Surface Method

Published on: May 12, 2023

1.7K

Related Experiment Videos

Last Updated: Mar 26, 2026

Optimization of the Epimedii Folium Mutton-Oil Processing Technology and Testing Its Effect on Zebrafish Embryonic Development
06:00

Optimization of the Epimedii Folium Mutton-Oil Processing Technology and Testing Its Effect on Zebrafish Embryonic Development

Published on: March 17, 2023

954
Formation of Dispersible Taohong Siwu Tablets
05:44

Formation of Dispersible Taohong Siwu Tablets

Published on: February 3, 2023

2.2K
Author Spotlight: Optimization of Processing Technology for Tiebangchui with Zanba Based on CRITIC Combined with Box-Behnken Response Surface Method
09:16

Author Spotlight: Optimization of Processing Technology for Tiebangchui with Zanba Based on CRITIC Combined with Box-Behnken Response Surface Method

Published on: May 12, 2023

1.7K

Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems

Background:

  • S (-) atenolol is a beta-blocker used for cardiovascular conditions.
  • Conventional oral dosage forms may present challenges in achieving sustained therapeutic drug levels.
  • Floating sustained release systems offer a promising approach to prolong drug release and improve patient compliance.

Purpose of the Study:

  • To develop and formulate floating sustained release matrix tablets of s (-) atenolol.
  • To optimize tablet formulations using response surface methodology.
  • To evaluate the drug release characteristics of the optimized floating tablets.

Main Methods:

  • Formulation of floating sustained release matrix tablets using hydroxypropyl methylcellulose, sodium bicarbonate, polyvinyl pyrrolidone, and lactose monohydrate.
  • Optimization using a 3(2) full factorial design to assess the impact of formulation variables on floating properties and drug release.
  • Analysis of drug release kinetics using Higuchi model and statistical analysis (ANOVA).

Main Results:

  • The developed s (-) atenolol floating tablets exhibited controlled buoyancy and sustained drug release.
  • The 3(2) factorial design effectively identified key formulation variables influencing tablet performance.
  • Drug release followed Higuchi kinetics, indicating an anomalous (non-Fickian) diffusion mechanism.

Conclusions:

  • Floating sustained release matrix tablets of s (-) atenolol were successfully developed and optimized.
  • The optimized formulation demonstrated favorable floating characteristics and sustained drug release profiles.
  • These novel floating tablets hold potential for improved therapeutic efficacy compared to conventional dosage forms.