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Design, Development and Optimization of S (-) Atenolol Floating Sustained Release Matrix Tablets Using Surface
P T Gunjal1, M B Shinde1, V S Gharge2
1Formulation and Development Department, Zuventus Healthcare Ltd, T-184 MIDC Bhosari, Pune-411 026, India.
Indian Journal of Pharmaceutical Sciences
|January 23, 2016
Summary
This study developed floating sustained release matrix tablets for s (-) atenolol using cellulose-based polymers. Optimized tablets demonstrated sustained drug release, offering potential therapeutic advantages over conventional formulations.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
Background:
- S (-) atenolol is a beta-blocker used for cardiovascular conditions.
- Conventional oral dosage forms may present challenges in achieving sustained therapeutic drug levels.
- Floating sustained release systems offer a promising approach to prolong drug release and improve patient compliance.
Purpose of the Study:
- To develop and formulate floating sustained release matrix tablets of s (-) atenolol.
- To optimize tablet formulations using response surface methodology.
- To evaluate the drug release characteristics of the optimized floating tablets.
Main Methods:
- Formulation of floating sustained release matrix tablets using hydroxypropyl methylcellulose, sodium bicarbonate, polyvinyl pyrrolidone, and lactose monohydrate.
- Optimization using a 3(2) full factorial design to assess the impact of formulation variables on floating properties and drug release.
- Analysis of drug release kinetics using Higuchi model and statistical analysis (ANOVA).
Main Results:
- The developed s (-) atenolol floating tablets exhibited controlled buoyancy and sustained drug release.
- The 3(2) factorial design effectively identified key formulation variables influencing tablet performance.
- Drug release followed Higuchi kinetics, indicating an anomalous (non-Fickian) diffusion mechanism.
Conclusions:
- Floating sustained release matrix tablets of s (-) atenolol were successfully developed and optimized.
- The optimized formulation demonstrated favorable floating characteristics and sustained drug release profiles.
- These novel floating tablets hold potential for improved therapeutic efficacy compared to conventional dosage forms.
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